Harmonizome 3.0

integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

Twirler mouse mutation, human homolog of

body length, human homolog of mouse body length 1

Tax1 (human T-cell leukemia virus type I) binding protein 1

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Tax1 (human T-cell leukemia virus type I) binding protein 3

This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]

Record to support submission of GeneRIFs for a gene not in Gene (human; man).

human coronavirus sensitivity

human papillomavirus (type 6a) integration site 1

human papilloma virus (type 18) integration site 1

human papillomavirus (type 18) integration site 2

human immunodeficiency virus type I enhancer binding protein 1

This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011]

human immunodeficiency virus type I enhancer binding protein 2

This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]

human immunodeficiency virus type I enhancer binding protein 3

This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]

Human herpesvirus 8, susceptibility to

human papillomavirus (type 18) E5 central sequence-like 1

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

coxsackievirus and adenovirus receptor-like

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 pseudogene

coxsackie virus and adenovirus receptor pseudogene 3

coxsackie virus and adenovirus receptor

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 pseudogene

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 pseudogene

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 pseudogene

BCL2/adenovirus E1B 19kDa interacting protein 3-like

This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]

coxsackievirus and adenovirus receptor pseudogene

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 7

coxsackievirus and adenovirus receptor-like

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 34

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 39

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 38

coxsackie virus and adenovirus receptor pseudogene 2

coxsackie virus and adenovirus receptor pseudogene 1

coxsackie virus and adenovirus receptor pseudogene

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 40

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 41

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 pseudogene

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 pseudogene

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 10

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 13

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 12

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 14

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 17

BCL2/adenovirus E1B 19kD interacting protein like

The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

BCL2/adenovirus E1B 19kDa interacting protein 1

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]

BCL2/adenovirus E1B 19kDa interacting protein 2

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

BCL2/adenovirus E1B 19kDa interacting protein 3

This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 20

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 21

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 22

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 23

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 24

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 25

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 26

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 27

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 29

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 pseudogene

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 8

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 5

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 4

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 6

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 1

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 3

BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 2

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 pseudogene