Harmonizome 3.0

ISL LIM homeobox 1

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term isl1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ISL1 from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Isl1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the ISL1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Isl1-Jak1-Stat3 complex protein complex from the CORUM Protein Complexes dataset.

From ChEA Transcription Factor Targets 2022

target genes of the ISL1-27105846-CHIP-SEQ-CPCS-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the ISL1-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the ISL1-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-ISL1-Members_of_the_ISL1_regulon_as_identified_by_SCENIC_ISL1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-ISL1-Unnamed_1_ISL1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-ISL1-Unnamed_2_ISL1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-ISL1-Unnamed_3_ISL1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-ISL1-Unnamed_4_ISL1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-ISL1-Unnamed_5_ISL1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-ISL1-Unnamed_6_ISL1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6488738-mmc6.xlsx-ISL1-Target_Gene_ISL1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.