Harmonizome 3.0

LIM homeobox 8

The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lhx8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for LHX8 from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Lhx8 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the LHX8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6488738-mmc6.xlsx-LHX8-Target_Gene_LHX8 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.