LIMS1 Gene

LIM and senescent cell antigen-like domains 1

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

LIMS1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for LIMS1 from the Pathway Commons Protein-Protein Interactions dataset.

Tmsb4x-Lims1-Ilk complex Gene Set

From CORUM Protein Complexes

proteins in the Tmsb4x-Lims1-Ilk complex protein complex from the CORUM Protein Complexes dataset.