Harmonizome 3.0

KDEL (Lys-Asp-Glu-Leu) containing 1 pseudogene 1

transfer RNA-Lys (TTT) 17-1

transfer RNA-Lys (TTT) 6-1

transfer RNA-Lys (TTT) 2-1

transfer RNA-Lys (TTT) 7-1

transfer RNA-Lys (TTT) 3-1

transfer RNA-Lys (TTT) 3-2

transfer RNA-Lys (TTT) 3-3

transfer RNA-Lys (TTT) 3-4

transfer RNA-Lys (CTT) 13-1

transfer RNA-Lys (CTT) 5-1

transfer RNA-Lys (CTT) 4-1

transfer RNA-Lys (TTT) 8-1

transfer RNA-Lys (TTT) 9-1

transfer RNA-Lys (CTT) 9-1

transfer RNA-Lys (CTT) 8-1

transfer RNA-Lys (TTT) 13-1

transfer RNA-Lys (TTT) 12-1

transfer RNA-Lys (CTT) 3-1

transfer RNA-Lys (CTT) 14-1

transfer RNA-Lys (CTT) 2-1

transfer RNA-Lys (CTT) 2-2

transfer RNA-Lys (CTT) 2-3

transfer RNA-Lys (CTT) 2-5

KDEL (Lys-Asp-Glu-Leu) containing 1

This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. This gene has multiple transcript variants which are predicted to encode distinct isoforms. [provided by RefSeq, Jan 2016]

KDEL (Lys-Asp-Glu-Leu) containing 2

Enables UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Mar 2025]

N-terminal Xaa-Pro-Lys N-methyltransferase 1

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

transfer RNA-Lys (CTT) 12-1

transfer RNA-Lys (TTT) 1-1

transfer RNA-Lys (CTT) 2-4

transfer RNA-Lys (CTT) 15-1

transfer RNA-Lys (TTT) 10-1

transfer RNA-Lys (TTT) 3-5

transfer RNA-Lys (TTT) 4-1

transfer RNA-Lys (TTT) 5-1

transfer RNA-Lys (CTT) 7-1

transfer RNA-Lys (CTT) 10-1

transfer RNA-Lys (CTT) 11-1

transfer RNA-Lys (CTT) 6-1

transfer RNA-Lys (TTT) 11-1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

transfer RNA-Lys (CTT) 16-1

transfer RNA-Lys (TTT) 15-1

transfer RNA-Lys (TTT) 16-1

transfer RNA-Lys (TTT) 14-1

transfer RNA-Lys (CTT) 1-2

transfer RNA-Lys (CTT) 1-1

N-terminal Xaa-Pro-Lys N-methyltransferase 2

Enables N-terminal protein N-methyltransferase activity. Involved in N-terminal protein amino acid methylation. Located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the Lys-kallidin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From DGIdb Drug Targets 2026

interacting proteins for the LYS-KALLIDIN drug from theDGIdb Drug Targets 2026 dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the Lys[Z(NO₂)]-Lys[Z(NO₂)] ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From DGIdb Drug Targets 2026

interacting proteins for the LYS[Z(NO2)]-LYS[Z(NO2)] drug from theDGIdb Drug Targets 2026 dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the Gly-His-Lys-6570 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the Gly-His-Lys-6575 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the Gly-His-Lys-6560 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical bradykinin, Lys-Leu(8)-desArg(9)- from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Leu-Ser-Lys-Leu peptide from the curated CTD Gene-Chemical Interactions dataset.

From DrugBank Drug Targets

interacting proteins for the Carbobenzoxy-Pro-Lys-Phe-Y(Po2)-Ala-Pro-Ome drug from the curated DrugBank Drug Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lys in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the H-c[Cys-Phe-LAgl(N^βMe benzoyl)-Trp-Lys-Thr-Phe-Cys]-OH ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the N-methyl-Phe-Lys-Pro-D-Cha-Cha-D-Arg-CO₂H ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Arg¹⁴Lys¹⁵]N/OFQ ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the H-c[Cys-Phe-LAgl(N^βMe benzoyl)-DTrp-Lys-Thr-Phe-Cys]-OH ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH₂ ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [¹⁹Lys ²⁶Leu]-galparan ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [tBaa¹ D-Tyr(Et)² Val⁴ Lys⁶ Arg-NH₂⁸ des-Gly⁹]AVP ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Lys¹⁵ Arg¹⁶ Leu²⁷]VIP-(1–7)/GRF-(8–27)-NH₂ ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [³H]Lys-[des-Arg⁹]BK ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the Ac-c[Cys-Glu-His-D-Phe-Arg-Trp-D-Cys]-Pro-Pro-Lys-Asp-NH₂ ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Phaa¹ D-Tyr(Et)² Val⁴ Lys⁶ Tyr-NH₂⁸ des-Gly⁹]AVP ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the Lys[Z(NO₂)]-Pro ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Lys⁵ Me-Leu⁹ Nle¹⁰]NKA-(4-10) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the fMet-Leu-Phe-Ile-Ile-Lys-FITC ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the Lys-CoA ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the Met-Lys-bradykinin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [D-Lys⁶]GnRH-II ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the Ac-Lys-[MeAla⁶ Leu⁸ des-Arg⁹]bradykinin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [³H]Lys-[Leu⁸][des-Arg⁹]BK ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the H-c[DCys-Phe-LAgl(N^βMe benzoyl)-DTrp-Lys-Thr-Phe-Cys]-OH ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the N-methyl-Phe-Lys-Pro-D-Cha-Trp-D-Arg-CO₂H ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Phaa¹ D-Tyr(Et)² Lys⁶ des-Gly⁹]AVP ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K10136726_Na-Tosyl-Lys Chloromethyl Ketone, Hydrochloride_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K10136726_Na-Tosyl-Lys Chloromethyl Ketone, Hydrochloride_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From DGIdb Drug Targets 2026

interacting proteins for the AC-LYS-[MEALA6,LEU8,DES-ARG9]BRADYKININ drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MET-LYS-BRADYKININ drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the [3H]LYS-[DES-ARG9]BK drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the [3H]LYS-[LEU8][DES-ARG9]BK drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the D-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-NAL-NH2 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the N-METHYL-PHE-LYS-PRO-D-CHA-CHA-D-ARG-CO2H drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the N-METHYL-PHE-LYS-PRO-D-CHA-TRP-D-ARG-CO2H drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the LYS-COA drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the AC-C[CYS-GLU-HIS-D-PHE-ARG-TRP-D-CYS]-PRO-PRO-LYS-ASP-NH2 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the LYS[Z(NO2)]-PRO drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the LYS[Z(NO2)]-VAL drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the H-C[CYS-PHE-LAGL(NΒME,BENZOYL)-DTRP-LYS-THR-PHE-CYS]-OH drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the H-C[CYS-PHE-LAGL(NΒME,BENZOYL)-TRP-LYS-THR-PHE-CYS]-OH drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the H-C[DCYS-PHE-LAGL(NΒME,BENZOYL)-DTRP-LYS-THR-PHE-CYS]-OH drug from theDGIdb Drug Targets 2026 dataset.