Harmonizome 3.0

mitogen-activated protein kinase kinase 5

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

MAP2K5 divergent transcript

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map2k5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase MAP2K5 from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP2K5 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP2K5 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From CORUM Protein Complexes

proteins in the Map2k5-Map3k3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MAP2K5-PRKCI-SQSTM1 complex protein complex from the CORUM Protein Complexes dataset.