Harmonizome 3.0

murine retrovirus integration site 1 homolog

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]

MRVI1 antisense RNA 1

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the MRVI1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MRVI1 from the Pathway Commons Protein-Protein Interactions dataset.