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MUC2 Genemucin 2, oligomeric mucus/gel-forming This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016] |
muc2 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term muc2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
MUC2 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for MUC2 from the Pathway Commons Protein-Protein Interactions dataset. |