Harmonizome 3.0

nuclear receptor subfamily 1, group H, member 4

This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]

From Pathway Commons Protein-Protein Interactions

interacting proteins for NR1H4 from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Nr1h4 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NR1H4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the NR1H4::RXRA transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.