Harmonizome 3.0

pregnancy-associated plasma protein A, pappalysin 1

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]

PAPPA antisense RNA 2

PAPPA antisense RNA 1

Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pappa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PAPPA from the Pathway Commons Protein-Protein Interactions dataset.

From HuBMAP Azimuth Cell Type Annotations

genes associated with the Mouse - Motor Cortex - Cluster - Sst+ Pappa+ GABAergic neuron cell type from the HuBMAP Azimuth Cell Type Annotations dataset.