Harmonizome 3.0

protein tyrosine kinase 2 beta

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ptk2b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase PTK2B from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PTK2B from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase PTK2B from the curated PhosphoSitePlus Substrates of Kinases dataset.

From CORUM Protein Complexes

proteins in the ITGAV-ITGB3-PXN-PTK2b complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ArgBP2a-CBL-PTK2B complex protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the EPI-1480-1 (PTK2B) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the EPI-2249-1 (PTK2B) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the SC-9019 (PTK2B) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.