Harmonizome 3.0

prune exopolyphosphatase

This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

prune homolog 2 (Drosophila)

The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

prune exopolyphosphatase pseudogene 1

prune exopolyphosphatase 1

This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

From HPO Gene-Disease Associations

genes associated with the prune belly phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the Prune belly syndrome phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Prune Belly Syndrome from the curated CTD Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Prune Belly Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores 2025

genes co-occuring with the disease Prune belly syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Prune belly syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CORUM Protein Complexes

proteins in the Prune-Gelsolin complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Prune-GSK3beta complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Prune/Nm23-H1 complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term prune in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the belly spot phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the belly blaze phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PRUNE from the Pathway Commons Protein-Protein Interactions dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the belly spot phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the abnormal digastric posterior belly morphology phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the belly blaze phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.