Harmonizome 3.0

SIX homeobox 3

This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]

SIX3 antisense RNA 1

Predicted to be involved in regulation of gene expression. [provided by Alliance of Genome Resources, Mar 2025]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term six3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SIX3 from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Six3 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SIX3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC5817105-thnov08p0972s2.xls-SIX3-GeneName_SIX3 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11263707-41419_2024_6896_MOESM6_ESM.pdf-67-SIX3-AS1_SIX3 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.