Harmonizome 3.0

SMAD specific E3 ubiquitin protein ligase 2

Enables SMAD binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Located in nuclear speck. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Mar 2025]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smurf2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein SMURF2 from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SMURF2 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SMURF2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the SMAD7-SMURF2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RNF11-SMURF2-STAMBP complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMURF2-SMAD3-SnoN complex, TGF(beta)-dependent protein complex from the CORUM Protein Complexes dataset.