Harmonizome 3.0

synaptosomal-associated protein, 25kDa

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

SNAP25 antisense RNA 1

Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Mar 2025]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term snap25 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SNAP25 from the Pathway Commons Protein-Protein Interactions dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX1a, CPLX1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX1a, CPLX1, CPLX3) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX1a, CPLX3, CPLX4) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (HGS, SNAP25, STX13) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (SNAP25, VAMP3, VAMP2, NAPB, STX13) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX1a, STX3, CPLX1, CPLX3, CPLX4) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX13) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX1a, CPLX2) protein complex from the CORUM Protein Complexes dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the SNAP25-related early-onset developmental and epileptic encephalopathy phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the SNAP25 related neurodevelopmental disorder phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.