Harmonizome 3.0

serglycin

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

From Pathway Commons Protein-Protein Interactions

interacting proteins for SRGN from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the SRGN gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From HuBMAP Azimuth Cell Type Annotations

genes associated with the Human - Motor Cortex - Cluster - NOSTRIN+ SRGN+ Layer 2-5 endothelial cell cell type from the HuBMAP Azimuth Cell Type Annotations dataset.

From HuBMAP ASCT+B Annotations

biomarker genes for the Brain_CT2_Endo L2-5 NOSTRIN SRGN cell type from the HuBMAP ASCT+B dataset.

From HuBMAP ASCT+B Augmented with RNA-seq Coexpression

biomarker genes for the Brain_CT2_Endo L2-5 NOSTRIN SRGN cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.