Harmonizome 3.0

sex determining region Y

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]

From ChEA Transcription Factor Targets

target genes of the SRY transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sry in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the SRY transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SRY from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the SRY transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SRY gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SRY-25088423-EMBRYONIC GONADS-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SRY-22984422-TESTIS-RAT transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transcription factor SRY protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease 46,Xy Gonadal Dysgenesis, Complete, Sry-Related in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease 46,Xy True Hermaphroditism, Sry-Related in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From ChEA Transcription Factor Targets 2022

target genes of the SRY-22984422-TESTIS-RAT transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the SRY-25088423-EMBRYONIC-GONADS-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11629026-VMS3-11-e70074-s003.xlsx-SRY-Gene_name_SRY transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.