Harmonizome 3.0

transient receptor potential cation channel, subfamily V, member 6

This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. Translation initiation for this protein occurs at a non-AUG start codon that is decoded as methionine. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Feb 2015]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term trpv6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for TRPV6 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the TRPV6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From DGIdb Drug Targets 2026

interacting proteins for the TRPV6 INHIBITOR CIS-22u2009A drug from theDGIdb Drug Targets 2026 dataset.