Harmonizome 3.0

Zic family member 3

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the ZIC3-20872845-MESC-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets

target genes of the ZIC3 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term zic3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ZIC3 from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Zic3 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the ZIC3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.