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PPIA Genepeptidylprolyl isomerase A (cyclophilin A) This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] |
ppia Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term ppia in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
PPIA Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for PPIA from the Pathway Commons Protein-Protein Interactions dataset. |
PPIA Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the PPIA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |