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SOD2 Genesuperoxide dismutase 2, mitochondrial This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016] |
sod2 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term sod2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
SOD2 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for SOD2 from the Pathway Commons Protein-Protein Interactions dataset. |
SOD2 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the SOD2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |