Harmonizome 3.0

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019]

transfer RNA-Thr (AGT) 4-1

transfer RNA-Thr (AGT) 1-3

transfer RNA-Thr (AGT) 1-2

transfer RNA-Thr (AGT) 1-1

transfer RNA-Thr (AGT) 3-1

transfer RNA-Thr (AGT) 5-1

transfer RNA-Thr (AGT) 2-2

transfer RNA-Thr (AGT) 6-1

transfer RNA-Thr (AGT) 2-1

transfer RNA-Thr (AGT) 7-1

From DGIdb Drug Targets 2026

interacting proteins for the AGT-182 drug from theDGIdb Drug Targets 2026 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term agt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the AGT ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for AGT from the Pathway Commons Protein-Protein Interactions dataset.