Harmonizome 3.0

MCM8 antisense RNA 1

minichromosome maintenance complex component 8

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]

From NURSA Protein Complexes

proteins in the BL1578 (MCM8) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the mcm8-mcm9 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the mcm8-mcm9 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the MCM8-ORC2-CDC6 complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mcm8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Cellular Component Annotations 2015

proteins localized to the mcm8-mcm9 complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From NURSA Protein Complexes

proteins in the BL268 (MCM8) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL269 (MCM8) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MCM8 from the Pathway Commons Protein-Protein Interactions dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the MCM8-MCM9 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the MCM8-MCM9 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the MCM8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.