Harmonizome 3.0

PRMT5 antisense RNA 1

protein arginine methyltransferase 5

This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

PRMT5 divergent transcript

coordinator of PRMT5, differentiation stimulator

Enables histone binding activity. Involved in chromatin remodeling. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

coordinator of PRMT5, differentiation stimulator pseudogene

From NURSA Protein Complexes

proteins in the BL3688 (PRMT5) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PRMT5 complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term prmt5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein arginine N-methyltransferase PRMT5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Coordinator of PRMT5 and differentiation stimulator protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein-Protein Interactions

interacting proteins for PRMT5 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PRMT5 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the PRMT5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From DGIdb Drug Targets 2026

interacting proteins for the PRMT5 INHIBITOR D3 drug from theDGIdb Drug Targets 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the PRMT5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.