Harmonizome 3.0

gem (nuclear organelle) associated protein 5

This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

From NURSA Protein Complexes

proteins in the BL5439 (GEMIN5) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the gemin3-gemin4-gemin5 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the SMN complex (GEMIN5,2,3,4, SMN) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMN complex (GEMIN5,4,3), SMN-independent intermediate protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemin5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From NURSA Protein-Protein Interactions

interacting proteins for GEMIN5 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for GEMIN5 from the Pathway Commons Protein-Protein Interactions dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Gemin3-Gemin4-Gemin5 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the GEMIN5-related neurodevelopmental disorder phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the GEMIN5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.