Harmonizome 3.0

nuclear transcription factor Y, alpha

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

From NURSA Protein Complexes

proteins in the BL8369 (NFYA) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From ENCODE Transcription Factor Targets

target genes of the NFYA transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfya in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the NFYA transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From NURSA Protein-Protein Interactions

interacting proteins for NFYA from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NFYA from the Pathway Commons Protein-Protein Interactions dataset.

From ChEA Transcription Factor Targets 2022

target genes of the NFYA-21822215-K562-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the NFYA transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NFYA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.