Harmonizome 3.0

EYA transcriptional coactivator and phosphatase 3

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]

From NURSA Protein Complexes

proteins in the BL9487 (EYA3) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From DEPOD Substrates of Phosphatases

substrates of the phosphatase EYA3 from the curated DEPOD Substrates of Phosphatases dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term eya3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for EYA3 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the EYA3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.