Harmonizome 3.0

cullin-associated and neddylation-dissociated 1

This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

uncharacterized LOC100130460

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cand1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CAND1 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the CAND1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the CAND1-CUL4B-RBX1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CAND1-CUL3-RBX1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CAND1-CUL2-RBX1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CAND1-CUL4A-RBX1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CAND1-CUL1-RBX1 complex protein complex from the CORUM Protein Complexes dataset.