Harmonizome 3.0

From DGIdb Drug Targets 2026

interacting proteins for the CAS-010 drug from theDGIdb Drug Targets 2026 dataset.

From CORUM Protein Complexes

proteins in the CAS-SRC-FAK complex protein complex from the CORUM Protein Complexes dataset.

From COSMIC Cell Line Gene CNV Profiles

genes with high or low copy number in CAS-1 relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

From COSMIC Cell Line Gene Mutation Profiles

genes mutated in the CAS-1 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

From GDSC Cell Line Gene Expression Profiles

genes with high or low expression in CAS-1 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cas in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the CAS family, DUF3513 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the CAS/CSE, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K20168484_1h-indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)- [cas]_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-A67552655_oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester- [cas]_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K37561857_3(2h)-pyridazinone, 6-[4-(difluoromethoxy)-3-methoxyphenyl]- [cas]_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K20168484_1h-indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)- [cas]_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K59456551_l-glutamic acid, n-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [cas]_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K22227508_l-ornithine, n5-[imino(methylamino)methyl]-[cas]_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K59456551_l-glutamic acid, n-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [cas]_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K59332007_2h-indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)- [cas]_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K59456551_l-glutamic acid, n-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [cas]_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From Sanger Dependency Map Cancer Cell Line Proteomics

proteins associated with the cell line CAS-1 from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.

From Reactome Pathways 2024

proteins participating in the Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) pathway from the Reactome Pathways 2024 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8819293-CAS-113-684-s008.docx-0-MYC_MYC transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8819293-CAS-113-684-s008.docx-0-MYC_1_MYC transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8409406-CAS-112-3585-s001.doc-2-Table_S3_Eleven_differentially_expressed_genes_between_R-CHOP_sensitive_and_resistant_patients_DDIT3 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8409406-CAS-112-3585-s001.doc-2-Table_S3_Eleven_differentially_expressed_genes_between_R-CHOP_sensitive_and_resistant_patients_1_DDIT3 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7894002-CAS-112-537-s001.docx-0-IKZF1_IKZF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7734002-CAS-111-4652-s002.docx-0-AR_AR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6361573-CAS-110-617-s002.docx-0-HIF1A_HIF1A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC5480077-CAS-108-1210-s002.docx-0-ZEB1_ZEB1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10728019-CAS-114-4732-s003.docx-0-ARID2_expressing_cells_ARID2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10728019-CAS-114-4732-s003.docx-0-KMT2B_expressing_cells_KMT2B transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10728019-CAS-114-4732-s003.docx-0-NFIB_expressing_cells_NFIB transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10823279-CAS-115-283-s001.xlsx-Table_S5-Table_S5_List_of_188_genes_particularly_up-regulated_by_AR_in_AILNCaP14_cells_AR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10823279-CAS-115-283-s001.xlsx-Table_S6-Table_S6_List_of_182_genes_particularly_down-regulated_by_AR_in_AILNCaP14_cells_AR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-40-RFX3_RFX3 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-48-PHF21A_PHF21A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-50-ZNF558_ZNF558 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-51-THAP5_THAP5 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-62-PAX6_PAX6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-70-HAND2_HAND2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-75-ZNF654_ZNF654 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-85-ZNF616_ZNF616 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-86-MGA_MGA transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-87-KLF8_KLF8 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-88-SOX21_SOX21 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-100-MBD2_MBD2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-103-ERF_ERF transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-104-HMBOX1_HMBOX1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-136-HES1_HES1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-138-CHAMP1_CHAMP1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-147-THAP9_THAP9 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-150-LBX2-AS1_LBX2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-158-IRF7_IRF7 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-171-JDP2_JDP2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-175-ZGLP1_ZGLP1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-237-RARB_RARB transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-239-THAP4_THAP4 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11462941-CAS-115-2947-s001.pdf-240-ZFX_ZFX transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11967273-CAS-116-1034-s006.pdf-0-TWIST2_TWIST2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC12317403-CAS-116-2064-s001.docx-0-AR_AR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC12400069-CAS-116-2427-s001.pdf-3-ZNF684_ZNF684 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.