Harmonizome 3.0

caveolin 1, caveolae protein, 22kDa

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cav1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CAV1 from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CAV1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CAV1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CORUM Protein Complexes

proteins in the TRP1-G alpha-11-IP3R3-CAV1 signaling complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the eNOS-CAV1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CAV1-VDAC1-ESR1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NOS3-CAV1-NOSTRIN complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the UTM-SGCE-DAG1-CAV1-NOS3 complex protein complex from the CORUM Protein Complexes dataset.