Harmonizome 3.0

MALT1 paracaspase

This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]

From NURSA Protein Complexes

proteins in the CBC361 (MALT1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CASP8-CHUK-IKBKB-MALT1-BCL10 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CARMA1-BCL10-MALT1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TRAF2-MALT1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TRAF6-MALT1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BCL10-MALT1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MALT1 oligomer complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CASP8-FADD-MALT1-BCL10 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FYB-CARMA1-BCL-10-MALT1 complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term malt1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From NURSA Protein Complexes

proteins in the BL9173 (MALT1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the EPI-1664-1 (MALT1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MALT1 from the Pathway Commons Protein-Protein Interactions dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Combined immunodeficiency due to MALT1 deficiency phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the MALT1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.