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CCL5 Genechemokine (C-C motif) ligand 5 This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
ccl5 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term ccl5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
CCL5 Gene SetFrom Guide to Pharmacology Protein Ligands of Receptors receptors of the CCL5 ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset. |
CCL5 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for CCL5 from the Pathway Commons Protein-Protein Interactions dataset. |
CCL5 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the CCL5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
CCL5 Gene Setinteracting proteins for the CCL5 drug from theDGIdb Drug Targets 2026 dataset. |
[125I]CCL5 (human) Gene SetFrom Guide to Pharmacology Chemical Ligands of Receptors receptors of the [125I]CCL5 (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. |
[125I]CCL5 (HUMAN) Gene Setinteracting proteins for the [125I]CCL5 (HUMAN) drug from theDGIdb Drug Targets 2026 dataset. |