Harmonizome 3.0

CD3d molecule, delta (CD3-TCR complex)

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd3d in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CD3D from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CD3D gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CORUM Protein Complexes

proteins in the Cd3d-Cd3g-Cd3e-Cd247 complex protein complex from the CORUM Protein Complexes dataset.