Harmonizome 3.0

cAMP responsive element binding protein 1

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the CREB1-15753290-HEK293T-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets 2022

target genes of the CREB1-15753290-HEK293T-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the CREB1-20920259-GC1-SPG-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the CREB1-23762244-HIPPOCAMPUS-RAT transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets

target genes of the CREB1 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From ENCODE Transcription Factor Targets

target genes of the CREB1 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term creb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Cellular Component Annotations 2015

proteins localized to the atf4-creb1 transcription factor complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CREB1 from the curated Hub Proteins Protein-Protein Interactions dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the CREB1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From NURSA Protein Complexes

proteins in the BL6388 (CREB1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CREB1 from the Pathway Commons Protein-Protein Interactions dataset.

From GO Cellular Component Annotations 2023

proteins localized to the ATF4-CREB1 transcription factor complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the CREB1-23762244-HIPPOCAMPUS-RAT transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the CREB1-20920259-GC1-SPG-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From Reactome Pathways 2024

proteins participating in the CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the CREB1 phosphorylation through the activation of Adenylate Cyclase pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde pathway from the Reactome Pathways 2024 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the ATF4-CREB1 transcription factor complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the ATF4-CREB1 transcription factor complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the CREB1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7902901-Table_12.xlsx-CREB1-Unnamed_7_CREB1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the CREB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.