Name

DDX58 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]

ddx58 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ddx58 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

DDX58 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DDX58 from the Pathway Commons Protein-Protein Interactions dataset.

Ubiquitin E3 ligase (TRIM25, DDX58) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (TRIM25, DDX58) protein complex from the CORUM Protein Complexes dataset.

DDX58/IFIH1-mediated induction of interferon-alpha/beta Gene Set

From Reactome Pathways 2024

proteins participating in the DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway from the Reactome Pathways 2024 dataset.

Negative regulators of DDX58/IFIH1 signaling Gene Set

From Reactome Pathways 2024

proteins participating in the Negative regulators of DDX58/IFIH1 signaling pathway from the Reactome Pathways 2024 dataset.