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DDX58 GeneDEAD (Asp-Glu-Ala-Asp) box polypeptide 58 DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020] |
ddx58 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term ddx58 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
DDX58 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for DDX58 from the Pathway Commons Protein-Protein Interactions dataset. |
Ubiquitin E3 ligase (TRIM25, DDX58) Gene Setproteins in the Ubiquitin E3 ligase (TRIM25, DDX58) protein complex from the CORUM Protein Complexes dataset. |
DDX58/IFIH1-mediated induction of interferon-alpha/beta Gene Setproteins participating in the DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway from the Reactome Pathways 2024 dataset. |
Negative regulators of DDX58/IFIH1 signaling Gene Setproteins participating in the Negative regulators of DDX58/IFIH1 signaling pathway from the Reactome Pathways 2024 dataset. |