Harmonizome 3.0

dystrophin

This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016]

DMD antisense RNA 3

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dmd in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for DMD from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the DMD gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From GEO Signatures of Differentially Expressed Genes for Diseases

genes differentially expressed during Duchenne muscular dystrophy (DMD)_Extraocular muscle_GSE1472 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

From GEO Signatures of Differentially Expressed Genes for Diseases

genes differentially expressed during Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE1026 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

From GEO Signatures of Differentially Expressed Genes for Diseases

genes differentially expressed during Duchenne muscular dystrophy (DMD)_Extraocular muscle_GSE1008 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

From GEO Signatures of Differentially Expressed Genes for Diseases

genes differentially expressed during Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) (MMHCC)_GSE1025 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Dmd-Associated Dilated Cardiomyopathy in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From WikiPathways Pathways 2024

proteins participating in the Abnormal calcium handling and its effects on muscle contraction in DMD pathway from the WikiPathways Pathways 2024 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the X-linked DMD-related dystrophinopathy phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.