Harmonizome 3.0

deoxyuridine triphosphatase

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

deoxyuridine triphosphatase pseudogene 2

deoxyuridine triphosphatase pseudogene 3

deoxyuridine triphosphatase pseudogene 1

deoxyuridine triphosphatase pseudogene 6

deoxyuridine triphosphatase pseudogene 7

deoxyuridine triphosphatase pseudogene 4

deoxyuridine triphosphatase pseudogene 5

deoxyuridine triphosphatase pseudogene 8

putative deoxyuridine 5'-triphosphate nucleotidohydrolase-like protein FLJ16323

Predicted to enable dUTP diphosphatase activity and magnesium ion binding activity. Predicted to be involved in dUMP biosynthetic process and dUTP catabolic process. [provided by Alliance of Genome Resources, Mar 2025]

deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like

From DrugBank Drug Targets

interacting proteins for the 2'-Deoxyuridine 3'-Monophosphate drug from the curated DrugBank Drug Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term deoxyuridine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Deoxyuridine metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Deoxyuridine triphosphate metabolite from the curated HMDB Metabolites of Enzymes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Deoxyuridine triphosphate nucleotidohydrolase/Deoxycytidine triphosphate deaminase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Deoxyuridine triphosphate nucleotidohydrolase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From GO Molecular Function Annotations 2023

genes performing the deoxyuridine phosphorylase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From MW Enzyme Metabolite Associations

interacting proteins for Deoxyuridine metabolite from the MW Gene Metabolite Associations dataset.

From GO Molecular Function Annotations 2025

genes performing the deoxyuridine phosphorylase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the DEOXYURIDINE MONOPHOSPHATE drug from theDGIdb Drug Targets 2026 dataset.