Harmonizome 3.0

eukaryotic translation initiation factor 2-alpha kinase 1

The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

From KEA Substrates of Kinases

substrates of the kinase EIF2AK1 from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for EIF2AK1 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase EIF2AK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the EIF2AK1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From Reactome Pathways 2024

proteins participating in the Response of EIF2AK1 (HRI) to heme deficiency pathway from the Reactome Pathways 2024 dataset.