Harmonizome 3.0

forkhead box P2

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

From ChEA Transcription Factor Targets

target genes of the FOXP2 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From ENCODE Transcription Factor Targets

target genes of the FOXP2 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term foxp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for FOXP2 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the FOXP2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the FOXP2 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the FOXP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the FOXP2-23625967-PFSK-1 AND SK-N-MC-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the FOXP2-21765815-NEURO2A-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets 2022

target genes of the FOXP2-23625967-PFSK-1-AND-SK-N-MC-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the FOXP2-21765815-NEURO2A-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.