Harmonizome 3.0

high mobility group box 1

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hmgb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for HMGB1 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HMGB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the HMGB1-HMGB2-HSC70-ERP60-GAPDH complex protein complex from the CORUM Protein Complexes dataset.

From GO Cellular Component Annotations 2023

proteins localized to the alphav-beta3 integrin-HMGB1 complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

From WikiPathways Pathways 2024

proteins participating in the Suppression of HMGB1 mediated inflammation by THBD pathway from the WikiPathways Pathways 2024 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the alphav-beta3 integrin-HMGB1 complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the alphav-beta3 integrin-HMGB1 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.