Harmonizome 3.0

interleukin 12A

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

IL12A antisense RNA 1

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il12a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL12A from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the IL12A gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CORUM Protein Complexes

proteins in the IL12A homodimer complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the IL12A-IL12B-IL12RB2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the IL12A-IL12B complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the IL12A-IL12B-IL12RB1 complex protein complex from the CORUM Protein Complexes dataset.