Harmonizome 3.0

interleukin 6

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL6 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the IL6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From GAD Gene-Disease Associations

genes associated with the disease plasma il6 levels in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease il6 transcription in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From PID Pathways

proteins participating in the IL6-mediated signaling events pathway from the PID Pathways dataset.

From WikiPathways Pathways 2024

proteins participating in the IL6 signaling pathway from the WikiPathways Pathways 2024 dataset.