Harmonizome 3.0

Nanog homeobox

The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

NANOG neighbor homeobox-like

Nanog homeobox pseudogene 8

This gene represents a transcribed retrogene of the Nanog homeobox gene. The putative encoded protein may participate in reprogramming of cancer cells. In vitro studies using a recombinant protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to the Nanog protein. [provided by RefSeq, Sep 2017]

Nanog homeobox pseudogene 9

Nanog homeobox pseudogene 6

Nanog homeobox pseudogene 7

Nanog homeobox pseudogene 4

Nanog homeobox pseudogene 5

Nanog homeobox pseudogene 2

Nanog homeobox pseudogene 3

Nanog homeobox pseudogene 1

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; regulation of transcription by RNA polymerase II; and stem cell population maintenance. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

NANOG neighbor homeobox

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

Nanog homeobox pseudogene 10

Nanog homeobox pseudogene 11

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the NANOG-18347094-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the NANOG-16153702-HESC-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the NANOG-21062744-HESC-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets

target genes of the NANOG transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From ENCODE Transcription Factor Targets

target genes of the NANOG transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nanog in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NANOG from the Pathway Commons Protein-Protein Interactions dataset.

From Reactome Pathways 2014

proteins participating in the POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation pathway from the Reactome Pathways dataset.

From ChEA Transcription Factor Targets 2022

target genes of the NANOG-21062744-HESCS-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the NANOG-16153702-HESCS-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the NANOG-19829295-ESCS-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the NANOG-20526341-ESCS-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the NANOG gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Reactome Pathways 2024

proteins participating in the POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation pathway from the Reactome Pathways 2024 dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Nanog transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6283862-41388_2018_370_MOESM14_ESM.xlsx-NANOG-NANOG_NANOG transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NANOG gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.