Harmonizome 3.0

NADH dehydrogenase (ubiquinone) complex I, assembly factor 1

This gene encodes a complex I assembly factor protein. Complex I (NADH-ubiquinone oxidoreductase) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. The encoded protein is required for assembly of complex I, and mutations in this gene are a cause of mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Dec 2011]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ndufaf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NDUFAF1 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NDUFAF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Respiratory chain complex I (incomplete NDUFAF1 assembly), mitochondrial protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ecsit complex (ECSIT, MT-CO2, NDUFA1, MT-ND1, TRAF6, NDUFAF1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ecsit complex (ECSIT, NDUFS3, NDUFAF1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Respiratory chain complex I (early intermediate NDUFAF1 assembly), mitochondrial protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ecsit complex (ECSIT, MT-CO2, GAPDH, TRAF6, NDUFAF1) protein complex from the CORUM Protein Complexes dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the Ecsit-NDUFAF1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.