Harmonizome 3.0

neuropilin 1

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nrp1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NRP1 from the Pathway Commons Protein-Protein Interactions dataset.

From CORUM Protein Complexes

proteins in the PlexinA1-NRP1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NRP1-VEGFR2-VEGF(165) complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FARP2-NRP1-PlexinA3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SEMA6D-PlexinA1-NRP1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FARP2-NRP1-PlexinA2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NRP1-VEGFC complex, heparin dependent protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ITGB1-NRP1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NRP1-VEGFD complex, heparin dependent protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PlexinA1-NRP1-SEMA3A complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FARP2-NRP1-PlexinA4 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FARP2-NRP1-PlexinA1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the VEGFA(165)-VEGFR2-NRP1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Nrp1-PlexinD1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the VEGFA(165)-KDR-NRP1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NRP1-VEGF(165/121) complex protein complex from the CORUM Protein Complexes dataset.

From WikiPathways Pathways 2024

proteins participating in the SARS CoV 2 altering angiogenesis via NRP1 pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the NRP1 triggered signaling in pancreatic cancer pathway from the WikiPathways Pathways 2024 dataset.