Harmonizome 3.0

phospholipase C, gamma 2 (phosphatidylinositol-specific)

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term plcg2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein PLCG2 from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PLCG2 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the PLCG2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the Autoinflammation, antibody deficiency, and immune dysregulation, plcg2-associated phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From NURSA Protein Complexes

proteins in the EPI-1931-1 (PLCG2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the EPI-2263-1 (PLCG2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Plcg2-Associated Antibody Deficiency And Immune Dysregulation in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.