Harmonizome 3.0

pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)

The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the PPBP ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PPBP from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the PPBP gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From LINCS L1000 CMAP Chemical Perturbation Consensus Signatures

genes differentially expressed following the 4-PPBP small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.