Harmonizome 3.0

prickle homolog 1 (Drosophila)

This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term prickle1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PRICKLE1 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the PRICKLE1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From DisGeNET Gene-Disease Associations

genes associated with the disease Prickle1-Related Progressive Myoclonus Epilepsy With Ataxia in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.