Harmonizome 3.0

protein kinase C, theta

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

PRKCQ antisense RNA 1

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term prkcq in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase PRKCQ from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PRKCQ from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase PRKCQ from the curated PhosphoSitePlus Substrates of Kinases dataset.