Name

TNP2 Gene

transition protein 2 (during histone to protamine replacement)

Predicted to enable zinc ion binding activity. Predicted to be involved in several processes, including penetration of zona pellucida; positive regulation of protein processing; and sperm DNA condensation. Predicted to act upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Predicted to be located in male germ cell nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

TNP1 Gene

transition protein 1 (during histone to protamine replacement)

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]

PRM1 Gene

protamine 1

Predicted to enable DNA binding activity. Predicted to be involved in chromosome organization and spermatogenesis. Predicted to act upstream of or within nucleus organization and spermatid development. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

PRM3 Gene

protamine 3

Predicted to enable DNA binding activity. Predicted to be involved in flagellated sperm motility. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

PRM2 Gene

protamine 2

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015]

Protamine P1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protamine P1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

protamine heparin aggregate Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical protamine heparin aggregate from the curated CTD Gene-Chemical Interactions dataset.

protamine Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term protamine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Protamine 2, PRM2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protamine 2, PRM2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

INSULIN ASPART PROTAMINE RECOMBINANT Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the INSULIN ASPART PROTAMINE RECOMBINANT drug from theDGIdb Drug Targets 2026 dataset.

INSULIN ASPART PROTAMINE, HUMAN Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the INSULIN ASPART PROTAMINE, HUMAN drug from theDGIdb Drug Targets 2026 dataset.

INSULIN LISPRO PROTAMINE RECOMBINANT Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the INSULIN LISPRO PROTAMINE RECOMBINANT drug from theDGIdb Drug Targets 2026 dataset.

INSULIN, PROTAMINE ZINC Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the INSULIN, PROTAMINE ZINC drug from theDGIdb Drug Targets 2026 dataset.